Metabolic Risk Markers in Women with Polycystic Ovarian Morphology
نویسندگان
چکیده
Polycystic ovary syndrome (PCOS) is a common endocrine condition in women of reproductive age, which is associated with a range of metabolic implications. Data concerning metabolic features of patients with polycystic ovarian morphology (POM) without any other PCOS diagnostic criteria (nonPCOS-POM) are limited. In the present study, metabolic profile of 46 women with nonPCOS-POM was investigated in comparison with 36 women with PCOS D phenotype and control group (N=146). PCOS D phenotype was defined according to the European Society for Human Reproduction and Embryology/American Society for Reproductive Medicine (ESHRE/ASRM) criteria as irregular anovulatory periods and POM. NonPCOS-POM patients in comparison to PCOS-D phenotype group showed a significantly lower waist circumference (73.0; 17.0; 99.5; 11.0; P<0.001), a homeostatic model assessment of insulin resistance (HOMA-IR) (1.1; 1.0; 12.8; 6.9; P<0.001) and a significantly higher fasting glucose-insulin ratio (FGIR) (15.2; 13.0; 5.9; 3.4; P<0.001). There was no significant difference in waist circumference, FGIR and HOMAIR between the nonPCOS-PMO and control group. As neither PCOS-D phenotype nor nonPCOS-POM patients are characterized by hyperandrogenism, our data suggest that hyperandrogenism is not the only factor contributing to the increased metabolic risk in women with PCOS D phenotype. NonPCOS-POM patients share a similar metabolic risk profile with the control population and could not be considered as patients with an increased metabolic risk.
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تاریخ انتشار 2010